Situation at a glance Since mid-February 2025, according to data available from sentinel sites, global SARS-CoV-2 activity has been increasing, with the test positivity rate reaching 11%, levels that have not been observed since July 2024. This rise is primarily observed in countries in the Eastern Mediterranean, South-East Asia, and Western Pacific regions. Since early 2025, global SARS-CoV-2 variant trends have slightly shifted.