The Princess Marie Louise Children's Hospital has marked its 100th anniversary with a renewed call for greater investment in child healthcare, urging government, the private sector and development partners to strengthen support for paediatric services to meet growing healthcare demands. The hospital, established in 1926 after Princess Marie Louise visited the then Gold Coast and witnessed the high rate of child mortality, has spent a century providing specialised healthcare to children and has become one of Ghana's leading paediatric referral centres. Over the years, the hospital has evolved from a modest facility treating nutritional deficiencies and infectious diseases into a major centre offering neonatal care, paediatric surgery, immunisation, nutritional rehabilitation and the management of communicable and non-communicable diseases, including sickle cell disease and HIV.